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GSH imbalance and depletion are reported in many other brain disorders, including autism [28,29], bipolar disorder [30], schizophrenia [31], amyotrophic lateral sclerosis [32], and multiple sclerosis [33]

7:11030 doi: 10.1038/ncomms11030 (2016)

Impact of Curcumin Delivery System Format on Bioaccessibility: Nanocrystals, Nanoemulsion Droplets, and Natural Oil Bodies

Reactive oxygen species and mitochondria: a nexus of cellular homeostasis

Based on such evolving biology, the 3Ts protocol integrates all available therapeutic tools, pharmacologic oxygenation (tadalafil), intralesional biologic regeneration (tunneling), and mechanical remodeling (traction) to promote true tissue restoration rather than simple deformity correction (Table 1)